Ret Proto-Oncogene anticorps (AA 702-848)

N° du produit ABIN6938321

Cet anticorps Souris Monoclonal détecte spécifiquement Ret Proto-Oncogene dans ELISA et Coat. Il présente une réactivité envers Humain.

Aperçu rapide pour Ret Proto-Oncogene anticorps (AA 702-848) (ABIN6938321)

Antigène: Ret Proto-Oncogene (RET)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Ret Proto-Oncogene est non-conjugé

Application: ELISA, Coating (Coat)

Clone: RET-2976

Détail du produit anti-Ret Proto-Oncogene anticorps

Épitope: AA 702-848

Specificité: The Ret proto-oncogene is structurally related to the growing family of tyrosine kinase transmembrane receptors and is involved in GDNF signaling. RET expression is reported in several regions of the central nervous system; in the developing cranial nerve ganglia and a subset of cells within dorsal root ganglia, in motor neurons in the spinal cord and hindbrain, in neuro-retina and the growing tips of the renal collecting ducts in developing kidney.Alterations in RETgene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung's disease.

Réactivité croisée (Details): Human.

Purification: 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.

Immunogène: Recombinant fragment (around aa 702-848) of human RET protein (exact sequence is proprietary)

Isotype: IgG1 kappa

Information d'application

Indications d'application:

Known_Application: ELISA (For coating, order Ab without BSA)Optimal dilution for a specific application should be determined.

Positive_Control: Breast, Prostate or Colon Carcinoma.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10 mM PBS, WITHOUT BSA and Azide.

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.

Date de péremption: 24 months

Détails sur Ret Proto-Oncogene

Antigène: Ret Proto-Oncogene (RET)

Autre désignation: RET

Sujet: Cadherin family member 12 (CDHF12), Cadherin related family member 16 (CDHR16), ELKS, HSCR1, Hydroxyaryl protein kinase, MEN2A, MEN2B, MTC1, Multiple endocrine neoplasia and medullary thyroid carcinoma 1, Oncogene RET, Proto-oncogene c-Ret, Proto-oncogene tyrosine-protein kinase receptor ret, PTC, RET, RET ELE1, RET51, RET9,RET Proto-oncogene
Cellular localisation: Cytoplasmic, Cell Surface and Nuclear

Poids moléculaire: 150kDa (precursor), 170kDa (Mature)

ID gène: 5979, 350321

UniProt: P07949

Pathways: Signalisation RTK, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation